Molecular analysis of even-skipped mutants in Drosophila development.
نویسندگان
چکیده
منابع مشابه
Molecular analysis of even-skipped mutants in Drosophila development.
The homeo box gene even-skipped (eve) plays a key role in the regulation of the Drosophila segmentation pattern. eve- embryos lack segment borders and show altered activities of several segmentation genes, including fushi tarazu (ftz), engrailed (en), and wingless (wg). Here, we present evidence that eve influences its own expression in a tissue-specific manner. Each of four different eve mutat...
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Axon pathfinding and target choice are governed by cell type-specific responses to external cues. Here, we show that in the Drosophila embryo, motorneurons with targets in the dorsal muscle field express the homeobox gene even-skipped and that this expression is necessary and sufficient to direct motor axons into the dorsal muscle field. Previously, it was shown that motorneurons projecting to ...
متن کاملA Careful Look at Binding Site Reorganization in the even-skipped Enhancers of Drosophila and Sepsids
In our recent PLoS Genetics paper [1] on the organization and activity of enhancers in the even-skipped gene of sepsid flies, we described, illustrated, analyzed, and discussed a series of small sequence blocks conserved between sepsid and Drosophila enhancers. We are thus rather surprised that Crocker and Erives [2] have announced the ‘‘discovery’’ of these conserved blocks in their Perspectiv...
متن کاملSepsid even-skipped Enhancers Are Functionally Conserved in Drosophila Despite Lack of Sequence Conservation
The gene expression pattern specified by an animal regulatory sequence is generally viewed as arising from the particular arrangement of transcription factor binding sites it contains. However, we demonstrate here that regulatory sequences whose binding sites have been almost completely rearranged can still produce identical outputs. We sequenced the even-skipped locus from six species of scave...
متن کاملAnalysis of function of the pair-rule genes hairy, even-skipped and fushi tarazu in mosaic Drosophila embryos.
We report the first attempt of its kind to study genetic interactions using young Drosophila embryos that are mosaic for wildtype and mutant cells. Using nuclear transplantation we make mosaic embryos in which a patch of cells lacks a particular segmentation gene, A. With antibodies, we than look at the expression of another gene that is known to be downstream of gene A, with respect to the cel...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1988
ISSN: 0890-9369
DOI: 10.1101/gad.2.12b.1824